Premiering in 2005, the long-running series has been through myriad changes over its 16 years on the air, including the evolution of its themes and plotlines, and the gradual rotation of most of its cast, so that the faces now seen each week on our TV screens are largely not the same ones viewers met during the show's first season. Grey's Anatomyis well into its seventeenth season of television, and the juggernaut medical drama will celebrate its Sweet 16 on March 27.
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